Lie to Me or Lie to Me* was an American television midseason replacement that premiered on the Fox network on January 21, 2009 to January 31, 2011 . In the show, Dr. Cal Lightman and his colleagues in The Lightman Group accept assignments from third parties (commonly local and federal law enforcement), and assist in investigations, reaching the truth through applied psychology: interpreting microexpressions, through the Facial Action Coding System, and body language. Dr. Lightman's character is based on Paul Ekman, notable psychologist and expert on body language and facial expressions.

The series is broadcast by Network Ten in Australia and Global TV in Canada, and also airs in Norway, Sweden and Belgium. Lie to Me aired on Sky1 in the UK and Ireland, starting on May 14, 2009. It is also planned for broadcast by RTL 5 in The Netherlands. In May 2009, the show was picked up by Fox for a second season consisting of 13 episodes. Lie to Me was cancelled by Fox on May 10, 2011